Distinct distal and proximal p53-binding sites in the MCK promoter govern the transcriptional response to p53
نویسندگان
چکیده
منابع مشابه
Kinetics of p53 binding to promoter sites in vivo.
Downstream target genes of p53 are thought to mediate its tumor-suppressive activity, but it is unknown whether differential transactivation of these genes is regulated at the level of p53 binding to their promoters. To address this issue, p53 binding in vivo to consensus sites in the p21(Waf1), MDM2, and PIG3 promoters was investigated in cells exposed to adriamycin (ADR) or ionizing radiation...
متن کاملP53 Binding Sites in Transposons
Definition of a consensus binding site for p53 by el-Deiry, W. Repeated regions of the genome harbor more functional information than commonly assumed. Two decades ago, a highly influential paper describing the consensus binding site for the key transcription factor p53 was published in Nature Genetics by el-Deiry et al. (1992). Recently, it has been observed that many p53 binding sites are spe...
متن کاملCharacterization of genome-wide p53-binding sites upon stress response
The tumor suppressor p53 is a sequence-specific transcription factor, which regulates the expression of target genes involved in different stress responses. To understand p53's essential transcriptional functions, unbiased analysis of its DNA-binding repertoire is pivotal. In a genome-wide tiling ChIP-on-chip approach, we have identified and characterized 1546 binding sites of p53 upon Actinomy...
متن کاملp53 Pathways to Simulate the p53 Transcriptional Activity
We have conducted some simulations of biological pathways with hybrid functional Petri net (HFPN) after careful reading of papers and developed a powerful simulation tool “Cell Illustrator [5]” (CI) for representing biological pathways with HFPN. In this study, by using CI, we constructed pathway of CDK-dependent phosphorylation pathway and ARF-dependent pathway, to observe the effect of the ph...
متن کاملTranscriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein.
In addition to serving a role as a DNA binding-dependent transcriptional activator, p53 has been reported to repress a variety of promoters that lack p53 binding sites. Data from recent studies have suggested that this activity is mediated via an interaction between p53 and the TATA box binding protein (TBP). To investigate the functional relevance of this interaction in vivo, we have performed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1997
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(97)00283-4